Journal article

Rationale and design of the African Cardiomyopathy and Myocarditis Registry Program: The IMHOTEP study


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Author list: Sarah M. Kraus a
, Gasnat Shaboodien a
, Veronica Francis a
, Nakita Laing a,d
, Jacqui Cirota a
, Ashley Chin a
,
Shahiemah Pandie a
, John Lawrenson b,c
, George A.M. Comitis b
, Barend Fourie c
, Liesl Zühlke a,b
,
Ambroise Wonkam a,d
, Helen Wainwright e
, Albertino Damasceno f
, Ana Olga Mocumbi g
, Lungile Pepeta h
,
Khulile Moeketsi i
, Baby M. Thomas i
, Kandathil Thomas i
, Makoali Makotoko j
, Stephen Brown j
,
Mpiko Ntsekhe a
, Karen Sliwa a
, Motasim Badri a,k
, Freedom Gumedze l
, Heather J. Cordell m, Bernard Keavney n
,
Vanessa Ferreira o
, Masliza Mahmod o
, Leslie T. Cooper p
, Magdi Yacoub q
, Stefan Neubauer o
, Hugh Watkins o
,
Bongani M. Mayosi a
, Ntobeko A.B. Ntusi a,
⁎, for the IMHOTEP Investigators:
Julius Mwita 1
, Ahmed El-Guindy 2
, Sir Magdi Yacoub 2
, Tolno Sandy Kola 3
, F. Ayub Barasa 4
,
Albertino Damasceno 5
, Ana Olga Mocumbi 6
, Okechukwu Ogah 7
, Motasim Badri 8
, James Russell 9
,
Ashley Chin 10, Sarah Kraus 10, Bongani Mayosi 10, Mpiko Ntsekhe 10, Ntobeko Ntusi 10, Karen Sliwa 10,
Ambroise Wonkam 10, Nakita Laing 10, Shaheen Pandie 10, Blanche Cupido 10, George Comitis 11,
John Lawrenson 11, Rik De Decker 11, Liesl Zühlke 11, Paul Brink 12, Barend Fourie 12, Marshall Heradien 12,
Lungile Pepeta 13, Nomlindo Makubalo 13, Mahlubandile Nxele 13, Benjamin Longo-Mbenza 14,
Khulile Moeketsi 14, Baby Thomas 14, Kandithalal Thomas 14, Makoali Makotoko 15, Stephen Brown 15,
Ahmed Suliman 16, Sulafa Ali 17, Kemilembe Tibazarwa 18, Charles Mondo 19, Michael Mungoma 20,
Bernard Keavney 21, Heather Cordell 22, Vanessa Ferreira 23, Masliza Mahmod 23, Stefan Neubauer 23,
Hugh Watkins 23, Leslie T. Cooper 24, Ellise Tapiwa Gambahay

Publication year: 2021

Journal: International Journal of Cardiology

Volume number: 333

Start page: 119

End page: 126

Number of pages: 8

ISSN: 0167-5273

eISSN: 1874-1754.



Background: Heart failure (HF), the dominant form of cardiovascular disease in Africans, is mainly due to hypertension, rheumatic heart disease and cardiomyopathy. Cardiomyopathies pose a great challenge because of poor prognosis and high prevalence in low- and middle-income countries (LMICs). Little is known about the etiology and outcome of cardiomyopathy in Africa. Specifically, the role of myocarditis and the genetic causes of cardiomyopathy are largely unidentified in Africans. Method: The African Cardiomyopathy and Myocarditis Registry Program (the IMHOTEP study) is a pan-African multi-centre, hospital-based cohort study, designed with the primary aim of describing the clinical characteristics, genetic causes, prevalence, management and outcome of cardiomyopathy and myocarditis in children and adults. The secondary aim is to identify barriers to the implementation of evidence-based care and provide a platform for trials and other intervention studies to reduce morbidity and mortality in cardiomyopathy. The registry consists of a prospective cohort of newly diagnosed (i.e., incident) cases and a retrospective (i.e., prevalent) cohort of existing cases from participating centres. Patients with cardiomyopathy and myocarditis will be subjected to a standardized 3-stage diagnostic process. To date, 750 patients have been recruited into the multi-centre pilot phase of the study. Conclusion: The IMHOTEP study will provide comprehensive and novel data on clinical features, genetic causes, prevalence and outcome of African children and adults with all forms of cardiomyopathy and myocarditis in Africa. Based on these findings, appropriate strategies for management and prevention of the cardiomyopathies in LMICs are likely to emerge.


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Last updated on 2025-23-10 at 13:11