The use of genomics methods and technologies for HIV research and public health holds potential in reducing the HIV burden in sub-Saharan Africa. ⇒ Continued innovation, improved access to care and strategies to reduce health inequities are essential to ensure better outcomes for children, adolescents and adults living with HIV globally. ⇒ Continued research into the biological and behavioural factors, as well as studies on immune changes, antiretroviral therapy toxicity and multiomics, will be essential for developing effective preventive and therapeutic intervention. ⇒ There is an urgent need for research on genetic factors underlying susceptibility to HIV and other coinfections and potential avenues for optimised HIV-coinfection treatment strategies.

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