Not available as its a correspondence..... A recent publication in this journal by Nisar et al. 1 assessed the effectiveness of various COVID-19 vaccines in Pakistan using a test- negative case-control design. They report moderate effectiveness of various vaccines and higher effectiveness mRNA vaccines compared with inactivated vaccines. Although they assessed the impact of concurrent medical conditions, they were only a few cases of im munosuppression contributing to < 3% of the study population and approximately 87% of the participants received Sinopharm and Si novac, and 1% received the Oxford/AstraZeneca vaccine. AstraZeneca (AZD1222), formerly called ChAdOx1, previously demonstrated ro bust immunogenicity after a single dose with favorable safety pro f iles. 2,3 Despite Botswana’s high HIV prevalence, treatment has bee

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