Journal article

Self-reported early-onset menopause among women living with HIV and hypertension in Botswana: a cross-sectional study


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Author list: Molefe-Baikai, Onkabetse Julia MMed, FCP1; Kebotsamang, Kago MSc2; Manyeagae, Gorata Duduzile MA2; Moshomo, Thato MMed, FCP1; Mawi, Moagedi BSc2; Mogaetsho, Edwin MSc1; Gaolathe, Tendani MD1,3; Molebatsi, Kesaobaka PhD3; Kelepile, Matlhogonolo PhD4; Kgotlaetsile, Keonayang MEd1; Leeme, Tshepo MMed, MSc3; Gala, Pooja MD, MPH5; Wang, Duolao PhD6; Hirschhorn, Lisa R. MD, MPH7; Mosepele, Mosepele MBBS, MSc1,3,8

Publication year: 2024

Journal: Menopause

eISSN: 1530-0374



he mean age (SD) of the 1,088 women enrolled was 59.1 (7.2) years, with 23.7% (n=258) having experienced early-onset menopause. The mean age (SD) at menopause overall was 47.4 (5.5) years and that for early-onset menopause was 40.3 (4.6) years. In adjusted analysis, the only predictor of early-onset menopause was HIV diagnosis before age 35 years (aRR=1.46; 95% CI: 1.06-2.01; P=0.020). CD4 count was inversely associated with the risk of early-onset menopause (aRR 0.98; 95% CI: 0.96-1.00; P=0.045).

Conclusions:

Early-onset menopause is relatively common among WLWH in Botswana and is associated with a younger age at HIV diagnosis. These findings highlight the need for integrated reproductive and HIV care, including screening and management of early-onset menopause to prevent menopause-related complications.


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Last updated on 2026-17-03 at 13:23