Journal article

Genetics and Geography of Leukocyte Telomere Length in Sub-Saharan Africans


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Publication Details

Author list: Steven C Hunt, Matthew E B Hansen, Simon Verhulst, Michael A McQuillan, William Beggs, Tsung-Po Lai, Dawit Wolde Meskel, Gurja Belay, Thomas B Nyambo, Christian C Abnet, Meredith Yeager, Stephen J Chanock, Michael A Province, Scott M Williams, Abraham Aviv, Sarah A Tishkoff.

Publisher: Published by Oxford University Press

Publication year: 2020

Journal acronym: Hum Mol Genet

Volume number: 29

Issue number: 18

Start page: 3014

End page: 3020

Number of pages: 7

ISSN: 0964-6906

URL: https://pdfs.semanticscholar.org/594a/5279bc3aaa968f2b1653c958b0aaf6e9c37f.pdf?_ga=2.64898415.1540243278.1661258719-1851799301.1657009075

Languages: English



Leukocyte telomere length (LTL) might be causal in cardiovascular disease and major cancers. To elucidate the roles of genetics and geography in LTL variability across humans, we compared LTL measured in 1295 sub-Saharan Africans (SSAs) with 559 African-Americans (AAms) and 2464 European-Americans (EAms). LTL differed significantly across SSAs (P = 0.003), with the San from Botswana (with the oldest genomic ancestry) having the longest LTL and populations from Ethiopia having the shortest LTL. SSAs had significantly longer LTL than AAms [P = 6.5(e-16)] whose LTL was significantly longer than EAms [P = 2.5(e-7)]. Genetic variation in SSAs explained 52% of LTL variance versus 27% in AAms and 34% in EAms. Adjustment for genetic variation removed the LTL differences among SSAs. LTL genetic variation among SSAs, with the longest LTL in the San, supports the hypothesis that longer LTL was ancestral in humans. Identifying factors driving LTL variation in Africa may have important ramifications for LTL-associated diseases.


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Last updated on 2022-29-11 at 11:32