Exome Sequencing Reveals a Putative Role for HLA-C*03:02 in Control of HIV-1 in African Pediatric Populations. - Research Portal

Journal article

Exome Sequencing Reveals a Putative Role for HLA-C*03:02 in Control of HIV-1 in African Pediatric Populations.

Authors/Editors

Mpoloka, Sununguko (Biological Sciences)

Williams, Lesedi (Biological Sciences)

Retshabile, Gaone (Biological Sciences)

Kasvosve, Ishmael (Faculty Of Health Sciences)

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Author list: Kyobe, Mwesigwa, Kisitu, Farirai, Katagirya, Mirembe, Ketumile, Wayengera, Katabazi, Kigozi, Wampande, Retshabile, Mlotshwa, Williams, Morapedi, Kasvosve, Kyosiimire-Lugemwa, Nsangi, Tsimako-Johnstone, Brown, Joloba, Anabwani, Bhekumusa, Mpoloka, Mardon, Matshaba, Kekitiinwa, Hanchard

Publication year: 2021

Journal name in source: Frontiers in genetics

Volume number: 12

ISSN: 1664-8021

URL: https://pubmed.ncbi.nlm.nih.gov/34512729/

Languages: English

= 0.18) between these alleles. These associations remained irrespective of gender or country. In one of the largest studies of HIV in Africa, we find evidence of a protective effect of canonical HLA-B alleles and a novel HLA-C association that appears to augment existing HIV-1 control alleles in pediatric populations. Our findings outline the value of using multi-ethnic populations in genetic studies and offer a novel HIV-1 association of relevance to ongoing vaccine studies.

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