Journal article

BF3OEt2 and MeSO3H-Promoted reactions of phenols and ethyl phenylpropiolate as a synthetic routes to neoflavones and a potential route to flavones


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Publication Details

Author list: Kgakatsi Nayang, Majinda Runner R. T., Masesane Ishmael B.

Publication year: 2022

Journal name in source: ARKIVOC

Journal acronym: ARKIVOC

ISSN: 1551-7004

Languages: English



The BF3.OEt2 and MeSO3H-promoted reactions of phenols and ethyl phenylpropiolate to give neoflavones in
17-96% and flavones in 0-25% yield are described. In general, phenols with activating substituents favor the
formation of neoflavones under both BF3.OEt2 and MeSO3H-promoted reaction conditions. Phenol and p-
Chlorophenol reacted with ethyl phenylpropiolate under the MeSO3H-promoted reaction conditions to give
close to 1:1 mixtures of the corresponding neoflavones and flavones.


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Last updated on 2022-29-11 at 11:34