Journal article
Dementia in Latin America: Paving the way toward a regional action plan.
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Publication Details Author list: Parra, Baez, Sedeño, Gonzalez Campo, Santamaría-García, Aprahamian, Bertolucci, Bustin, Camargos Bicalho, Cano-Gutierrez, Caramelli, Chaves, Cogram, Beber, Court, de Souza, Custodio, Damian, de la Cruz, Diehl Rodriguez, Brucki, Fajersztajn, Farías, De Felice, Ferrari, de Oliveira, Ferreira, Ferretti, Figueredo Balthazar, Ferreira Frota, Fuentes, García, Garcia, de Gobbi Porto, Duque Peñailillo, Engler, Maier, Mata, Gonzalez-Billault, Lopez, Morelli, Nitrini, Quiroz, Guerrero Barragan, Huepe, Pio, Suemoto, Kochhann, Kochen, Kumfor, Lanata, Miller, Mansur, Hosogi, Lillo, Llibre Guerra, Lira, Lopera, Comas, Avila-Funes, Sosa, Ramos, Resende, Snyder, Tarnanas, Yokoyama, Llibre, Cardona, Possin, Kosik, Montesinos, Moguilner, Solis, Ferretti-Rebustini, Ramirez, Matallana, Mbakile-Mahlanza, Marques Ton, Tavares, Miotto, Muniz-Terrera, Muñoz-Nevárez, Orozco, Okada de Oliveira, Piguet, Pintado Caipa, Piña Escudero, Schilling, Rodrigues Palmeira, Yassuda, Santacruz-Escudero, Serafim, Smid, Slachevsky, Serrano, Soto-Añari, Takada, Grinberg, Teixeira, Barbosa, Trépel, Ibanez Publication year: 2021 Journal name in source: Alzheimer's & dementia : the journal of the Alzheimer's Association Volume number: 17 Issue number: 2 Start page: 295 End page: 313 Number of pages: 19 ISSN: 1552-5260 |
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
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