In Africa, a systematic appraisal of the associated pattern of psychiatric disorders (PDs) among health-care workers (HCWs) is lacking. We, therefore, aimed to ascertain the pattern of PDs and their associated risk factors among HCWs in Africa during the Coronavirus Disease 2019 pandemic. We identified 12 studies for inclusion after searching four databases: Web of Science, PubMed, AJOL, and EBSCOhost for articles written in English from January 2020 to April 2021. Anxiety disorder with rates from 9.5% to 73.3% and depression, 12.5% to 71.9%, were the most reported PDs. Availability of protective gear and information regarding preventive measures reduced the risk of developing any PDs, while psychoactive substance use, history of chronic medical illness, low level of resilience, and low social support increased these risks. A considerable proportion of HCWs manifest various psychological problems such as their counterparts in other parts of the world. Multiple factors were also implicated as risk, albeit associations were not consistently established across the studies. There is a need to increase research capacity tailored to the HCW population's needs in the continent.

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