Journal article

Effects of sex and alcohol use on antiretroviral therapy outcomes in Botswana: a cohort study.

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Author list: Gross, Bellamy, Ratshaa, Han, Steenhoff, Mosepele, Bisson

Publication year: 2017

Journal name in source: Addiction (Abingdon, England)

Volume number: 112

Issue number: 1

Start page: 73

End page: 81

Number of pages: 9

ISSN: 0965-2140



AIMS\nDESIGN\nSETTING\nPARTICIPANTS\nMEASUREMENTS\nFINDINGS\nCONCLUSION\nTo determine alcohol use effect on HIV treatment success and whether alcohol use mediates the relation between male sex and treatment failure.\nLongitudinal cohort study.\nEight HIV clinics in and near Gaborone, Botswana.\n copies/ml.\nPrimary outcome was a composite of treatment failure over 6 months including death, lost to care or plasma HIV RNA > 25 copies/ml. Exposures included alcohol use and gender.\nFailure in 339 (36%) participants included 40 (4%) deaths, 194 (21%) lost to care and 105 (11%) with HIV RNA > 25 copies/ml. Both hazardous alcohol use in the past year [adjusted odds ratio (aOR) = 1.4, 95% confidence interval (CI) = 1.0, 1.9] and male sex (aOR = 2.1, 95% CI = 1.5, 2.9) were associated with failure. Hazardous alcohol use in the year prior to enrollment was more common in men (57%) than women (24%), P < 0.001. There was no difference in alcohol use effect on failure between sexes (P for interaction > 0.5). Controlling for hazardous alcohol use did not change the relation between sex and failure.\nAlcohol use among HIV-infected adults in Botswana appears to worsen HIV treatment outcomes. Alcohol use does not appear to have either a mediating or a moderating effect on the relation between gender and HIV treatment outcome failure.


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Last updated on 2025-02-12 at 11:32