Book chapter abstract

Chapter 18 - Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injury


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Publication Details

Author list: Kemelo K

Edition name or number: Academic Press (An imprint of Elsevier)

Publication year: 2021

Title of series: SIRTUIN BIOLOGY IN MEDICINE

Start page: 295

End page: 308

Number of pages: 14

URL: https://www.sciencedirect.com/science/article/abs/pii/B9780128141182000148



Xenobiotic-induced hepatotoxicity is a particularly important research field for therapeutics. There are numerous hepatotoxins but a limited number of hepatoprotective drugs. Oxidative stress plays a key role in hepatotoxicity. Over the past decade, polyphenols have gained more attention, due to their ameliorative involvement in a myriad of oxidative stress-related diseases. Likewise, the stress-responsive histone deacetylase, sirtuin 1 (SIRT1), has been the focus of the greatest investigation as a potential gateway to the many positive health benefits of polyphenols. In this chapter, we focus on the therapeutic potential of SIRT1-activating compounds in experimental models of xenobiotic-induced hepatotoxicity and the role of SIRT1 in hepatoprotection/hepatotoxicity.


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Last updated on 2025-28-02 at 09:51